Injection of dermal fillers is the second most frequent nonsurgical cosmetic procedure performed in the world. Dermal fillers are an option in the treatment of volume deficiency, scars, and rhytides; facial sculpting; facial contouring; and augmentation of specific anatomical sites such as the lips. The number of injectable dermal fillers available on the market increases yearly. This paper extensively reviews the properties of the available fillers, such as their longevity, available combinations, clinical indications and adverse effects, and how these properties affect the choice of filler agent for a particular patient or a particular site. Also, future trends in the advancement of dermatological aesthetics been discussed.