The present investigation was focused on the preliminary phytochemical and Fourier Transform Infrared Spectral analysis of Cyclea peltata (Lamk.) Hook. The aqueous and organic solvent extracts (ethanol, Benzene, chloroform, acetone and Petroleum ether) from the rhizome part of Cyclea peltata (Menispemaceae) were tested for the availability of alkaloids, glycosides,, phenolic compounds, saponins, tannins, flavonoids, terpenoids, steroids, phobatannins, coumarins, proteins, emodins and carbohydrates. The FT-IR spectrum showed the presence of alkyne (C-H), methylene (C-H), (O-H) stretch, (C-N) stretch, (C-O) group, (N-H) stretch, p-directing benzene ring, organic nitrates, aliphatic nitro compounds, ammonium ion and aromatic nitro compounds. The results confirm the fact that this plant posses important bioactive constituents useful for our health so further scientific investigation is needed.