The transdermal anti-inflammatory gels containing Lornoxicam & different polymers, were prepared and evaluated for different parameters like pH, drug content & rheological properties like viscosity & spredability and results found were all satisfactory. The Results indicates that PLO gel shows better results than Carbopol Gel. All eleven formulations were also evaluated for In-vitro drug release study. Study was carried for 8 hrs for all formulation and results reported in table 9.3 shows that, the Formulation F-2 and F-4 showed good cumulative % Drug Release profile of Lornoxicam in 8 hr. But the linear curve shown in fig. 9.1 was obtained from F-2 formulation. The cumulative amount permeated from Carbopol gel through membrane was found to be 67% which was less than PLO Gel formulations. This indicates that PLO Gel has more drug permeation across the membrane than carbopol gel.