In the present study, the effects of a natural superdisintegrants, Plantago ovata and starch of Solanum tuberosum with synthetic superdisintegrants like sodium starch glycolate (SSG) and croscarmellose sodium were compared in the formulations of fast dissolving tablets (FDT). FDTs of Amoxicillin Trihydrate (model drug) were prepared by direct compression method using microcrystalline cellulose as it lends itself as direct compressible vehicle. So formulated tablets were evaluated for different test parameters viz., weight variation, hardness, disintegration time, drug content, friability, dissolution test etc. Swelling index was also investigated with an aim to compare all the factors like swelling property, in-vitro disintegration and dispersion time along with its in-vitro release rates for all the superdisintegrants. Hence, the present study revealed that this natural superdisintegrant (Plantago ovata mucilage) shows better disintegrating property than the most widely used synthetic superdisintegrants like SSG and Ac-Di-Sol in the formulations of FDTs.