Nanogel are nanoparticles composed of a hydrogel that is high cross-linked physically and chemically with hydrophilic polymer chain. Particle size range of nanogel is varies from 20-200nm. The basic things which help to make nanogel as an effectively drug delivery system, that is the nanogel based ingredients have exalted loading capacity, biodegradability and biocompatibility. They have a massive drug loading capacity and it shows superior permeation capacities due to its smaller size. The route of administration are various types, they are oral, nasal, parenteral, pulmonary, intra-ocular and topical. Biomedical and Pharmaceutical application of nanogel have been explored for tissue regeneration, surgical device, wound healing, rectal, vaginal, implementation and peroral, ocular and transdermal drug delivery. Nanogel are the neoteric drug delivery system that can make-out an integral part in denoting many issues related to old and modern courses of treatment such as nonspecific effect and poor stability. Nanogel are on of the way in nanotechnology which has been most confine in successful drug delivery inside the body and in addition topical treatment. So, nanogel make a good position in medical science, in future it is use for the treatment of diabetes, bone regulation, inflammation and cancer, etc.