Smoking increases blood pressure; decreases exercise tolerance and increase the tendency for blood to clot. Smoking decreases HDL. Smokers are insulin resistance exhibit several aspects of the insulin resistance syndrome, and are at an increased risk for type - II diabetes. In diabetic patients, smoking also promotes the development and progression of diabetic macro vascular diseases, particularly diabetic nephropathy. Estimation of Glucose, cholesterol HDL-cholesterol, triglycerides, urea, creatinine and uric acid Hence the results of our present study clearly demonstrates that, diabetic smokers are at a higher risk of developing deleterious complications such as ischaemic heart disease and renal dysfunctions in comparison with the diabetic non-smokers.