Naringenin, a flavanone found in citrus fruits, has sparked widespread scientific attention due to its various pharmacological properties. This systematic review evaluates all preclinical investigations completed in the recent decade (2020-2025) to understand naringenin's medicinal potential. It has been shown to be effective in the treatment of a variety of pathological illnesses, including cancer, osteoporosis, neurodegenerative diseases, metabolic disorders, and inflammatory diseases. Naringenin's mechanisms of action include antioxidant, anti-inflammatory, anti-apoptotic, and immunomodulatory pathways. Recent advances in nanoformulations and drug delivery devices have improved bioavailability and therapeutic effectiveness.