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VOL. 10, ISSUE 1 (2025)
Plasma levels of vitamin-D and C-reactive protein in adult Indian patients with COVID-19
Authors
Ravi Prakash, R.B Singh
Abstract
Vitamin D deficiency (VDD) has been associated
with increased mortality in patients with COVID-19. The anti-inflammatory
properties of vitamin D are vital when considering the heightened inflammation
in COVID-19 patients. Although avalanche of reports are available on the plasma
levels of vitamin D and C-reactive protein (CRP) in COVID-19 patients,
Information on the dynamics of CRP level changes in different categories of
vitamin D status is lacking. Therefore, the plasma levels of CRP were
determined in COVID-19 patients with different vitamin D status. Forty-nine
adults comprising 31 COVID-19 patients and 18 apparently healthy participants
who served as controls were enrolled into this study. The plasma levels of high
sensitivity-CRP (hsCRP) and vitamin D were determined using ELISA. Vitamin D
status was classified as deficient, insufficient, sufficient and intoxication
as appropriate. None of the COVID-19 patients had vitaznin D insufficiency
while majority of the controls were vitamin D sufficient. The proportion of
COVID-19 patients with vitamin D intoxication was significantly higher than in
the controls. The median plasma levels of vitamin D and hsCRP were not
significantly different between the COVID-19 patients and the controls. The
median plasma level of hsCRP was slightly lower in the vitamin D intoxication
group compared with the vitamin D sufficient group. Vitamin D intoxication is
common among Indian patients with COVID-19 and the vitamin D. intoxication is
associated with low plasma hsCRP level. There is the need for public
enlightenment on the dangers inherent in vitamin D supplement abuse in Indians
patients.
Pages:35-38
How to cite this article:
Ravi Prakash, R.B Singh "Plasma levels of vitamin-D and C-reactive protein in adult Indian patients with COVID-19". International Journal of Pharmaceutical Science and Research, Vol 10, Issue 1, 2025, Pages 35-38
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